Nf1 Haploinsufficiency Alters Myeloid Lineage Commitment and Function, Leading to Deranged Skeletal Homeostasis.

@article{Rhodes2015Nf1HA,
  title={Nf1 Haploinsufficiency Alters Myeloid Lineage Commitment and Function, Leading to Deranged Skeletal Homeostasis.},
  author={Steven D. Rhodes and Hao Yang and Ruizhi Dong and Keshav Menon and Yongzheng He and Zhaomin Li and Shi Chen and Karl W. Staser and Li Jiang and Xiaohua Wu and X Frank Yang and Xianghong Peng and Khalid S. Mohammad and Theresa A. Guise and Mingjiang Xu and Fengchun Yang},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2015},
  volume={30 10},
  pages={1840-51}
}
Although nullizygous loss of NF1 leads to myeloid malignancies, haploinsufficient loss of NF1 (Nf1) has been shown to contribute to osteopenia and osteoporosis which occurs in approximately 50% of neurofibromatosis type 1 (NF1) patients. Bone marrow mononuclear cells of haploinsufficient NF1 patients and Nf1(+/-) mice exhibit increased osteoclastogenesis and accelerated bone turnover; however, the culprit hematopoietic lineages responsible for perpetuating these osteolytic manifestations have… CONTINUE READING
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