Next generation sequencing of the hepatitis C virus NS5B gene reveals potential novel S282 drug resistance mutations.


Identifying HCV drug resistance mutations (DRMs) is increasingly important as new direct acting antiviral therapies (DAA) become available. Tagged pooled pyrosequencing (TPP) was originally developed as cost-effective approach for detecting low abundance HIV DRMs. Using 127 HCV-positive samples from a Canadian injection drug user cohort, we demonstrated the… (More)
DOI: 10.1016/j.virol.2014.12.037


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