Next-generation sequencing is a credible strategy for blood group genotyping.

  title={Next-generation sequencing is a credible strategy for blood group genotyping.},
  author={Yann Fichou and M. Audr{\'e}zet and Paul Gu{\'e}guen and C{\'e}dric Le Mar{\'e}chal and Claude F{\'e}rec},
  journal={British journal of haematology},
  volume={167 4},
Although several medium/high-throughput tools have been engineered for molecular analysis of blood group genes, they usually rely on the targeting of single nucleotide polymorphisms, while other variants remain unidentified. To circumvent this limitation a strategy for genotyping blood group genes by next-generation sequencing (NGS) was set up. Libraries consisting of exons, flanking introns and untranslated regions of 18 genes involved in 15 blood systems were generated by the Ion AmpliSeq… CONTINUE READING
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