Next-generation sequencing indicates false-positive MRD results and better predicts prognosis after SCT in patients with childhood ALL

@article{Kotrova2017NextgenerationSI,
  title={Next-generation sequencing indicates false-positive MRD results and better predicts prognosis after SCT in patients with childhood ALL},
  author={Michaela Kotrova and Vincent H. J. van der Velden and Jacques J. M. van Dongen and Renata Form{\'a}nkov{\'a} and Petr Sedl{\'a}cek and Monika Br{\"u}ggemann and Jan Zuna and Jan Star{\'y} and Jan Trka and Eva Froňkov{\'a}},
  journal={Bone Marrow Transplantation},
  year={2017},
  volume={52},
  pages={962-968}
}
Minimal residual disease (MRD) monitoring via quantitative PCR (qPCR) detection of Ag receptor gene rearrangements has been the most sensitive method for predicting prognosis and making post-transplant treatment decisions for patients with ALL. Despite the broad clinical usefulness and standardization of this method, we and others have repeatedly reported the possibility of false-positive MRD results caused by massive B-lymphocyte regeneration after stem cell transplantation (SCT). Next… CONTINUE READING
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patients guided by minimal residual disease level before stem cell transplantation

  • van der Velden VHJ, van Dongen JJM
  • 2010

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