Next-generation sequencing identifies the natural killer cell microRNA transcriptome.

  title={Next-generation sequencing identifies the natural killer cell microRNA transcriptome.},
  author={Todd A Fehniger and Todd Wylie and Elizabeth A. Germino and Jeffrey W. Leong and Vincent J. Magrini and Sunita B Koul and Catherine R. Keppel and Stephanie E. Schneider and Daniel C. Koboldt and Ryan P. Sullivan and M. Elizabeth Heinz and Seth D. Crosby and Rakesh Nagarajan and Giridharan Ramsingh and Daniel C. Link and Timothy J. Ley and Elaine R. Mardis},
  journal={Genome research},
  volume={20 11},
Natural killer (NK) cells are innate lymphocytes important for early host defense against infectious pathogens and surveillance against malignant transformation. Resting murine NK cells regulate the translation of effector molecule mRNAs (e.g., granzyme B, GzmB) through unclear molecular mechanisms. MicroRNAs (miRNAs) are small noncoding RNAs that post-transcriptionally regulate the translation of their mRNA targets, and are therefore candidates for mediating this control process. While the… CONTINUE READING


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Comprehensive evaluation of microRNA genes and gene expression using next generation sequencing in a patient with acute myelogenous leukemia

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