Next-generation sequencing identifies high frequency of mutations in potentially clinically actionable genes in sebaceous carcinoma.

@article{Tetzlaff2016NextgenerationSI,
  title={Next-generation sequencing identifies high frequency of mutations in potentially clinically actionable genes in sebaceous carcinoma.},
  author={Michael T Tetzlaff and Rajesh R. Singh and Elena G. Seviour and Jonathan L Curry and Courtney W Hudgens and Diana Bell and Daniel A Wimmer and Jing Ning and Bogdan A. Czerniak and Li Zhang and Michael A. Davies and Victor G Prieto and Russell R. Broaddus and Prahlad T. Ram and Rajyalakshmi Luthra and B Esmaeli},
  journal={The Journal of pathology},
  year={2016},
  volume={240 1},
  pages={84-95}
}
Sebaceous carcinoma (SC) is a rare but aggressive malignancy with frequent recurrence and metastases. Surgery is the mainstay of therapy, but effective systemic therapies are lacking because the molecular alterations driving SC remain poorly understood. To identify these, we performed whole-exome next-generation sequencing of 409 cancer-associated genes on 27 SCs (18 primary/locally recurrent ocular, 5 paired metastatic ocular, and 4 primary extraocular) from 20 patients. In ocular SC, we… CONTINUE READING
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