Next-generation sequencing for hereditary breast and gynecologic cancer risk assessment

@article{Kurian2015NextgenerationSF,
  title={Next-generation sequencing for hereditary breast and gynecologic cancer risk assessment},
  author={Allison W. Kurian and Kerry Kingham and James M. Ford},
  journal={Current Opinion in Obstetrics and Gynecology},
  year={2015},
  volume={27},
  pages={23–33}
}
Purpose of review To summarize advances in next-generation sequencing and their application to breast and gynecologic cancer risk assessment. Recent findings Next-generation sequencing panels of 6–112 cancer-associated genes are increasingly used in patient care. Studies report a 4–16% prevalence of mutations other than BRCA1/2 among patients who meet evidence-based practice guidelines for BRCA1/2 testing, with a high rate (15–88%) of uninterpretable variants of uncertain significance. Despite… 

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