Next-generation sequencing applied to molecular diagnostics.

@article{Natrajan2011NextgenerationSA,
  title={Next-generation sequencing applied to molecular diagnostics.},
  author={Rachael Natrajan and Jorge S Reis-Filho},
  journal={Expert review of molecular diagnostics},
  year={2011},
  volume={11 4},
  pages={
          425-44
        }
}

• Rachael Natrajan, Jorge S Reis-Filho
• Published in Expert review of molecular diagnostics 2011
• DOI:10.1586/erm.11.18

Next-generation sequencing technologies have begun to revolutionize the field of cancer genetics through rapid and accurate assessment of a patient's DNA makeup with minimal cost. These technologies have already led to the realization of the inter- and intra-tumor genetic heterogeneity and the identification of novel mutations and chimeric genes, however, several challenges lie ahead. Given the low number of recurrent somatic genetic aberrations in common types of cancer, the identification of… CONTINUE READING

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