Next-generation proteomics: towards an integrative view of proteome dynamics

  title={Next-generation proteomics: towards an integrative view of proteome dynamics},
  author={A. F. Maarten Altelaar and Javier Mu{\~n}oz and Albert J. R. Heck},
  journal={Nature Reviews Genetics},
Next-generation sequencing allows the analysis of genomes, including those representing disease states. However, the causes of most disorders are multifactorial, and systems-level approaches, including the analysis of proteomes, are required for a more comprehensive understanding. The proteome is extremely multifaceted owing to splicing and protein modifications, and this is further amplified by the interconnectivity of proteins into complexes and signalling networks that are highly divergent… 

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