Next-generation flexible formats of VNAR domains expand the drug platform's utility and developability.

  title={Next-generation flexible formats of VNAR domains expand the drug platform's utility and developability.},
  author={Obinna C. Ubah and Magdalena J Buschhaus and L. Ferguson and M. Kovaleva and J. Steven and A. Porter and C. Barelle},
  journal={Biochemical Society transactions},
  volume={46 6},
  • Obinna C. Ubah, Magdalena J Buschhaus, +4 authors C. Barelle
  • Published 2018
  • Computer Science, Medicine
  • Biochemical Society transactions
  • Therapeutic mAbs have delivered several blockbuster drugs in oncology and autoimmune inflammatory disease. Revenue for mAbs continues to rise, even in the face of competition from a growing portfolio of biosimilars. Despite this success, there are still limitations associated with the use of mAbs as therapeutic molecules. With a molecular mass of 150 kDa, a two-chain structure and complex glycosylation these challenges include a high cost of goods, limited delivery options, and poor solid… CONTINUE READING
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