• DOI:10.1042/BST20180177
Corpus ID: 53170787

Next-generation flexible formats of VNAR domains expand the drug platform's utility and developability.

@article{Ubah2018NextgenerationFF,
  title={Next-generation flexible formats of VNAR domains expand the drug platform's utility and developability.},
  author={Obinna C. Ubah and Magdalena J Buschhaus and L. Ferguson and M. Kovaleva and J. Steven and A. Porter and C. Barelle},
  journal={Biochemical Society transactions},
  year={2018},
  volume={46 6},
  pages={
          1559-1565
        }
}

Obinna C. Ubah, Magdalena J Buschhaus, +4 authors C. Barelle

Published 2018

Computer Science, Medicine

Biochemical Society transactions

Therapeutic mAbs have delivered several blockbuster drugs in oncology and autoimmune inflammatory disease. Revenue for mAbs continues to rise, even in the face of competition from a growing portfolio of biosimilars. Despite this success, there are still limitations associated with the use of mAbs as therapeutic molecules. With a molecular mass of 150 kDa, a two-chain structure and complex glycosylation these challenges include a high cost of goods, limited delivery options, and poor solid… CONTINUE READING

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