Next-Generation Digital Information Storage in DNA

  title={Next-Generation Digital Information Storage in DNA},
  author={George M. Church and Yuan Gao and Sriram Kosuri},
  pages={1628 - 1628}
Digital information can be stored in DNA at densities higher than digital media such as flash memory or quantum holography. Digital information is accumulating at an astounding rate, straining our ability to store and archive it. DNA is among the most dense and stable information media known. The development of new technologies in both DNA synthesis and sequencing make DNA an increasingly feasible digital storage medium. We developed a strategy to encode arbitrary digital information in DNA… 

DNA-Based Digital Storage

  • Computer Science
  • 2017
The practical and technical issues being addressed to further develop DNA synthesis intersection of the synthetic biology and information technology industries are discussed, highlighting how the convergence of research in these areas will accelerate discovery in both.

DNA and the Digital Data Storage

The application of DNA data storage is limited due to such disadvantages as high cost, time-consuming, lack of random access ability, however, the seen advances in DNA sequencing technology positively shine the future of DNA digital data storage.

Reading and writing digital data in DNA

This protocol describes encoding of digital files as DNA and the error-free retrieval of the stored data from the sequenced data, offering an ideal starting point for small experiments.

Enzymatic DNA synthesis for digital information storage

A de novo enzymatic DNA synthesis strategy designed from the bottom-up for information storage is established, and a template-independent DNA polymerase is harnessed for controlled synthesis of sequences with user-defined information content.

Capacity-approaching DNA storage

This work reports a strategy to store and retrieve DNA information that is robust and approaches the theoretical maximum of information that can be stored per nucleotide and opens the possibility of highly reliable DNA-based storage that approaches the information capacity of DNA molecules and enables virtually unlimited data retrieval.

Toward practical high-capacity low-maintenance storage of digital information in synthesised DNA

An in vitro approach is developed that represents the information being stored as a hypothetical long DNA molecule and encodes this using shorter DNA fragments and demonstrates DNA-storage to be a realistic technology for large-scale digital archiving that may already be cost-effective for low access, multi-century-long archiving tasks.

Next Generation Information Storage Technology: DNA Data Storage

Due to the advantages of high storage density and long storage time, DNA storage can meet the needs of big data storage, and it is possible to replace silicon-based materials as the next generation of information storage technology.

Digital Data Storage on DNA

The method described can be used to store text data in DNA by compressing, storing multiple copies along with providing security to data.

Digital Data Storage on DNA

The method described can be used to store text data in DNA by compressing, storing multiple copies along with providing security to data.

Molecular digital data storage using DNA

How DNA can be adopted as a storage medium for custom data, as a potential future complement to current data storage media such as computer hard disks, optical disks and tape is discussed.



Length-based encoding of binary data in DNA.

This letter reports on the encoding of 12 bits of data in a DNA fragment of 110 nucleotides and the process of recovering the data.

Alignment‐Based Approach for Durable Data Storage into Living Organisms

A simple, flexible, and robust data storage and retrieval method based on sequence alignment of the genomic DNA of living organisms for stable and compact data storage without the need for template DNA, parity checks, or error‐correcting algorithms is introduced.

An improved Huffman coding method for archiving text, images, and music characters in DNA.

An improved Huffman coding method for information storage in DNA and a plasmid-based library with efficient and reliable information retrieval and assembly with uniquely designed primers is described.

Quantum holographic encoding in a two-dimensional electron gas.

It is shown that it is possible to exceed this limit with a holographic method that is based on electron wavefunctions rather than free-space optical waves, and involves placing tens of bits of information into a single fermionic state.

Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome

The design, synthesis, and assembly of the 1.08–mega–base pair Mycoplasma mycoides JCVI-syn1.0 genome starting from digitized genome sequence information and its transplantation into a M. capricolum recipient cell to create new cells that are controlled only by the synthetic chromosome are reported.

Organic data memory using the DNA approach

For very long-term storage and retrieval, encode information as artificial DNA strands and insert into living hosts to store and retrieval for hundreds of millions of years.

Hiding messages in DNA microdots

This work has developed a DNA-based, doubly steganographic technique for sending secret messages that is first camouflaged within the enormous complexity of human genomic DNA and then further concealed by confining this sample to a microdot.

Genome sequencing. Search for pore-fection.

Oxford Nanopore Technologies is set to achieve the first commercialization of a long-awaited and oft-doubted technology called nanopore sequencing. The technology, based on protein pores so tiny that

Synthesis of high-quality libraries of long (150mer) oligonucleotides by a novel depurination controlled process

It is shown that the depurination side reaction is the limiting factor for the synthesis of libraries of long oligonucleotides on Agilent Technologies’ SurePrint® DNA microarray platform and the characterization of synthesis efficiency for such libraries is reported.

Bistability in Atomic-Scale Antiferromagnets

It is shown that antiferromagnetic nanostructures, composed of just a few Fe atoms on a surface, exhibit two magnetic states, the Néel states, that are stable for hours at low temperature.