News 02-Winter 2005 / 06 in vivo-jetPEI TM mediates effi cient delivery of bioactive siRNA in animals

@inproceedings{Erbacher2005News02,
  title={News 02-Winter 2005 / 06 in vivo-jetPEI TM mediates effi cient delivery of bioactive siRNA in animals},
  author={Patrick Erbacher and Anne-Laure Bolcato Bellemin and Barbara A Demeneix},
  year={2005}
}
Figure 1: Inhibition of luciferase gene expression in the lungs after tail vein injection of siRNA and pCMVLuc complexed with in vivojetPEITM Forty micrograms of pCMVLuc (GL2Luc) with or without 10 μg of siRNA (GL2or GL3-siRNA) and complexed with in vivo-jetPEITM at N/P ratio of 8 in 200 μl of 5% glucose solution were injected in the tail vein of nude mice. As control, mice were injected with 10 μg of siRNA targeting a different gene (GL3) and the same amount of pCMVLuc. Twenty four hours later… CONTINUE READING