Newly synthesized anticancer drug HUHS1015 is effective on malignant pleural mesothelioma

@article{Kaku2014NewlySA,
  title={Newly synthesized anticancer drug HUHS1015 is effective on malignant pleural mesothelioma},
  author={Yoshiko Kaku and Hisao Nagaya and Ayako Tsuchiya and Takeshi Kanno and Akinobu Gotoh and Akito Tanaka and Tadashi Shimizu and Syuhei Nakao and Chiharu Tabata and Takashi Nakano and Tomoyuki Nishizaki},
  journal={Cancer Science},
  year={2014},
  volume={105},
  pages={883 - 889}
}
The newly synthesized naftopidil analogue HUHS1015 reduced cell viability in malignant pleural mesothelioma cell lines MSTO‐211H, NCI‐H28, NCI‐H2052, and NCI‐H2452, with the potential greater than that for the anticancer drugs paclitaxel or cisplatin at concentrations higher than 30 μM. HUHS1015 induced both necrosis and apoptosis of MSTO‐211H and NCI‐H2052 cells. HUHS1015 upregulated expression of mRNAs for Puma, Hrk, and Noxa in MSTO‐211H and NCI‐H2052 cells, suggesting HUHS1015‐induced… 
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