Newly produced T and B lymphocytes and T-cell receptor repertoire diversity are reduced in peripheral blood of fingolimod-treated multiple sclerosis patients.

@article{Chiarini2015NewlyPT,
  title={Newly produced T and B lymphocytes and T-cell receptor repertoire diversity are reduced in peripheral blood of fingolimod-treated multiple sclerosis patients.},
  author={Marco Chiarini and Alessandra Sottini and Diego Bertoli and Federico Serana and Luigi Caimi and Sarah Rasia and Ruggero Capra and Luisa Imberti},
  journal={Multiple sclerosis},
  year={2015},
  volume={21 6},
  pages={726-34}
}
BACKGROUND Fingolimod inhibits lymphocyte egress from lymphoid tissues, thus altering the composition of the peripheral lymphocyte pool of multiple sclerosis patients. OBJECTIVE The objective of this paper is to evaluate whether fingolimod determines a decrease of newly produced T- and B-lymphocytes in the blood and a reduction in the T-cell receptor repertoire diversity that may affect immune surveillance. METHODS Blood samples were obtained from multiple sclerosis patients before… CONTINUE READING
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