Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: Where are the insulin resistance genes?

@article{Florez2008NewlyIL,
  title={Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: Where are the insulin resistance genes?},
  author={Jose C Florez},
  journal={Diabetologia},
  year={2008},
  volume={51},
  pages={1100-1110}
}
Although type 2 diabetes has been traditionally understood as a metabolic disorder initiated by insulin resistance, it has recently become apparent that an impairment in insulin secretion contributes to its manifestation and may play a prominent role in its early pathophysiology. The genetic dissection of Mendelian and, more recently, polygenic types of diabetes confirms the notion that primary defects in insulin synthesis, processing and/or secretion often give rise to the common form of this… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 126 extracted citations

Disease Gene Identification

Methods in Molecular Biology • 2018
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 100 references

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.

The Journal of clinical investigation • 2007
View 6 Excerpts
Highly Influenced

Common variants in HNF-1 α and risk of type 2 diabetes

Diabetologia • 2006
View 9 Excerpts
Highly Influenced

Discovery of rare variants in MODY genes and impact on progression to diabetes in the Diabetes Prevention Program (DPP)

J McAteer, KA Jablonski, TI Pollin
ADA Annual Scientific Sessions Abstracts 392-OR. http://professional. diabetes.org/Abstracts_Display.aspx?TYP=1&CID=55551, • 2007
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…