Newly identified degradation products of ceftiofur and cephapirin impact the analytical approach for quantitative analysis of kidney.

Abstract

This paper describes our research on the degradation of ceftiofur and cephapirin at physiological temperatures in kidney extract and in alkaline and acidic solution, conditions that regularly occur during sample preparation. Degradation products were identified using LC-ToF/MS, NMR and microbiological techniques. Additionally kinetics of the degradation… (More)
DOI: 10.1016/j.chroma.2009.04.003

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