Newly identified biologically active and proteolysis-resistant VEGF-A isoform VEGF111 is induced by genotoxic agents

@article{Mineur2007NewlyIB,
  title={Newly identified biologically active and proteolysis-resistant VEGF-A isoform VEGF111 is induced by genotoxic agents},
  author={Pierre Mineur and Alain C. Colige and Christophe. F. Deroanne and Johanne Dubail and Fr{\'e}d{\'e}ric Kesteloot and Yvette Habraken and Agn{\'e}s No{\"e}l and Stefan A V{\"o}{\"o} and Johannes Waltenberger and Charles Maurice Lapiere and Betty V. Nusgens and Charles Lambert},
  journal={The Journal of Cell Biology},
  year={2007},
  volume={179},
  pages={1261 - 1273}
}
Ultraviolet B and genotoxic drugs induce the expression of a vascular endothelial growth factor A (VEGF-A) splice variant (VEGF111) encoded by exons 1-4 and 8 in many cultured cells. Although not detected in a series of normal human and mouse tissue, VEGF111 expression is induced in MCF-7 xenografts in nude mice upon treatment by camptothecin. The skipping of exons that contain proteolytic cleavage sites and extracellular matrix-binding domains makes VEGF111 diffusible and resistant to… CONTINUE READING