Newly identified autoantibodies: relationship to idiopathic inflammatory myopathy subsets and pathogenesis.

@article{Gunawardena2008NewlyIA,
  title={Newly identified autoantibodies: relationship to idiopathic inflammatory myopathy subsets and pathogenesis.},
  author={Harsha Gunawardena and Zoe E. Betteridge and N J Mchugh},
  journal={Current opinion in rheumatology},
  year={2008},
  volume={20 6},
  pages={675-80}
}
PURPOSE OF REVIEW There is increasing evidence that patients with polymyositis and dermatomyositis have specific clinico-serological profiles. Myositis-specific autoantibodies target intracellular proteins involved in key processes such as translocation and nuclear transcription, and are closely linked to patterns of disease expression. This review highlights the recent work on novel myositis-specific autoantibodies, their autoantigen targets, the relationship to clinical subsets and potential… CONTINUE READING

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