Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen

@article{Haynes2005NewlyGC,
  title={Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen},
  author={Laura Haynes and Sheri M. Eaton and Eve M. Burns and Troy D. Randall and Susan L Swain},
  journal={The Journal of Experimental Medicine},
  year={2005},
  volume={201},
  pages={845 - 851}
}
Using a T cell receptor transgenic (TCR Tg) mouse model, we have shown that TCR Tg CD4 cells from aged mice retain a naive phenotype, but exhibit reduced proliferation and IL-2 production in response to the antigen compared with cells from young mice. We hypothesize that age-related decreases in T cell function may be partly related to the age of the T cells. Because thymic output is decreased with age, peripheral T cells in older individuals are likely to be older than those in younger… CONTINUE READING

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