Newly described activating JAK3 mutations in T-cell acute lymphoblastic leukemia

  title={Newly described activating JAK3 mutations in T-cell acute lymphoblastic leukemia},
  author={Tarunpreet Bains and Michael C Heinrich and Marc M. Loriaux and Carol Beadling and Dylan A Nelson and Andrea L Warrick and Tanaya L Neff and Jeffrey W. Tyner and Jennifer B Dunlap and Christopher L . Corless and Guang Fan},
T-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease that accounts for 10–15% of adult and 25% of childhood ALL cases. Despite advances in therapy of T-ALL, relapsed disease remains a leading cause of death. The genetic and biological determinants of treatment failure and clinical outcomes remain incompletely understood. The JAK/STAT signaling cascade is essential in hematopoiesis, and somatic mutations of JAK1, JAK2 and JAK3 have been reported in a wide variety of… CONTINUE READING
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Jak 1 has a dominant role over Jak 3 in signal transduction through g ccontaining cytokine receptors

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