Newer insights into premeiotic development of germ cells in adult human testis using Oct-4 as a stem cell marker.

@article{Bhartiya2010NewerII,
  title={Newer insights into premeiotic development of germ cells in adult human testis using Oct-4 as a stem cell marker.},
  author={Deepa Bhartiya and Sandhya Kasiviswanathan and Sreepoorna K Unni and Prasad Pethe and Jayesh V. Dhabalia and Sujata Kiran Patwardhan and Hemant B. Tongaonkar},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={2010},
  volume={58 12},
  pages={1093-106}
}
The transcription factor octamer-binding transforming factor 4 (Oct-4) is central to the gene regulatory network responsible for self-renewal, pluripotency, and lineage commitment in embryonic stem (ES) cells and induced pluripotent stem cells (PSCs). This study was undertaken to evaluate differential localization and expression of two major transcripts of Oct-4, viz. Oct-4A and Oct-4B, in adult human testis. A novel population of 5- to 10-μm PSCs with nuclear Oct-4A was identified by ISH and… CONTINUE READING
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