Newer Approaches to the Treatment of Acne Vulgaris

@article{Simonart2012NewerAT,
  title={Newer Approaches to the Treatment of Acne Vulgaris},
  author={Thierry Simonart},
  journal={American Journal of Clinical Dermatology},
  year={2012},
  volume={13},
  pages={357-364}
}
  • T. Simonart
  • Published 12 December 2012
  • Medicine
  • American Journal of Clinical Dermatology
The multifactorial etiology of acne vulgaris makes it challenging to treat. Current treatments include topical retinoids, benzoyl peroxide, topical and systemic antibiotics, azelaic acid, and systemic isotretinoin. Adjunctive and/or emerging approaches include topical dapsone, taurine bromamine, resveratrol, chemical peels, optical treatments, as well as complementary and alternative medications. The purpose of this paper is to discuss the therapies available for acne and their latest… 

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References

SHOWING 1-10 OF 91 REFERENCES

Current state of acne treatment: highlighting lasers, photodynamic therapy, and chemical peels.

Light and laser therapy, photodynamic therapy, chemical peels, and comedo extraction are growing in popularity as adjunctive treatments and may offer alternatives to those who desire better efficacy, quicker onset of action, improved safety profile, reduced risk of antibiotic resistance, and non-systemic administration.

Topical Retinoids in Acne Vulgaris

The broad anti-acne activity and safety profile of topical retinoids justifies their use as first-line treatment in most types of non-inflammatory and inflammatory acne.

Topical taurine bromamine, a new candidate in the treatment of moderate inflammatory acne vulgaris: a pilot study.

The concept that TauBr can be used as a topical agent in the treatment of acne vulgaris, especially in patients who have already developed antibiotic resistance, is supported.

An evaluation of dapsone gel 5% in the treatment of acne vulgaris

Clinical studies indicate dapsone gel 5% is effective in treating mild to moderately severe acne, and pharmacokinetic evidence indicating topical dosing in comparison to oral administration significantly reduces systemic concentrations of the drug, and therefore risk of serious side effects.

Laser treatment of acne vulgaris.

Fractional photothermolysis, the 1450-nm diode laser, and pulsed dye lasers have been used in the nonablative treatment of acne scars with significant success.

Isotretinoin: state of the art treatment for acne vulgaris

  • R. GancevicieneC. Zouboulis
  • Medicine
    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • 2010
Physician's experience, coupled with proper patient selection, dose adjustment or discontinuation of treatment, and routine monitoring for potential toxicity, has allowed the successful prevention and management of most adverse effects associated with isotretinoin.

Harnessing the anti-inflammatory effects of topical dapsone for management of acne.

  • L. Kircik
  • Medicine, Biology
    Journal of drugs in dermatology : JDD
  • 2010
Data suggest the vehicle formulation enhances healing and contributes to tolerability, making topical dapsone 5% gel a worthwhile anti-inflammatory treatment for many patients with mild-to-moderate acne vulgaris.

Acne vulgaris

Benzoyl peroxide development, pharmacology, formulation and clinical uses in topical fixed-combinations.

  • J. Harper
  • Medicine
    Journal of drugs in dermatology : JDD
  • 2010
Benzoyl peroxide (BPO) is a commonly used and highly effective topical treatment for acne that is available in concentrations from 2.5-10%. The compound is not associated with bacterial resistance,

Efficacy of the addition of salicylic acid to clindamycin and benzoyl peroxide combination for acne vulgaris

The addition of SA to CDP and BPO treatment demonstrated significantly better and faster results in terms of reductions in acne lesion counts and well tolerated except for higher frequency of mild to moderate transient dryness.
...