Newcastle disease virus may enter cells by caveolae-mediated endocytosis.

  title={Newcastle disease virus may enter cells by caveolae-mediated endocytosis.},
  author={Celia M. Cant{\'i}n and Javier Holguera and Laura Ferreira and Enrique Villar and Isabel Mu{\~n}oz-Barroso},
  journal={The Journal of general virology},
  volume={88 Pt 2},
The entry into cells of Newcastle disease virus (NDV), a prototype member of the paramyxoviruses, is believed to occur by direct fusion at the plasma membrane through a pH-independent mechanism. In addition, NDV may enter host cells by an endocytic pathway. Treatment of cells with drugs that block caveolae-dependent endocytosis reduced NDV fusion and infectivity, the degree of inhibition being dependent on virus concentration. The inhibitory effect was reduced greatly when drugs were added… CONTINUE READING
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