Newcastle disease virus evolution. I. Multiple lineages defined by sequence variability of the hemagglutinin-neuraminidase gene.

@article{Sakaguchi1989NewcastleDV,
  title={Newcastle disease virus evolution. I. Multiple lineages defined by sequence variability of the hemagglutinin-neuraminidase gene.},
  author={Takemasa Sakaguchi and Tetsuya Toyoda and Bin Gotoh and N. M. Inocencio and Kei-ichi Kuma and Takashi Miyata and Yoshiyuki Nagai},
  journal={Virology},
  year={1989},
  volume={169 2},
  pages={260-72}
}
We compared the hemagglutinin-neuraminidase gene sequence among 13 strains of Newcastle disease virus (NDV) isolated over the last 50 years. Although overall homology was remarkably high, the sequence variability demonstrated the existence of at least three distinct lineages, which must have co-circulated for considerable periods. The sequence variability also appears to reflect some accumulation of mutations over time. Strictly correlating with the lineages, the translation products could be… CONTINUE READING

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