Newcastle Disease Virus (NDV)-Based Assay Demonstrates Interferon-Antagonist Activity for the NDV V Protein and the Nipah Virus V, W, and C Proteins

@article{Park2003NewcastleDV,
  title={Newcastle Disease Virus (NDV)-Based Assay Demonstrates Interferon-Antagonist Activity for the NDV V Protein and the Nipah Virus V, W, and C Proteins},
  author={Man-Seong Park and M. Shaw and J. Mu{\~n}oz-Jord{\'a}n and J. Cros and T. Nakaya and N. Bouvier and P. Palese and A. Garc{\'i}a-Sastre and C. Basler},
  journal={Journal of Virology},
  year={2003},
  volume={77},
  pages={1501 - 1511}
}
ABSTRACT We have generated a recombinant Newcastle disease virus (NDV) that expresses the green fluorescence protein (GFP) in infected chicken embryo fibroblasts (CEFs). This virus is interferon (IFN) sensitive, and pretreatment of cells with chicken alpha/beta IFN (IFN-α/β) completely blocks viral GFP expression. Prior transfection of plasmid DNA induces an IFN response in CEFs and blocks NDV-GFP replication. However, transfection of known inhibitors of the IFN-α/β system, including the… Expand
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