Corpus ID: 38222406

Newborns develop a Th1-type immune response to Mycobacterium bovis bacillus Calmette-Guérin vaccination.

@article{Marchant1999NewbornsDA,
  title={Newborns develop a Th1-type immune response to Mycobacterium bovis bacillus Calmette-Gu{\'e}rin vaccination.},
  author={Arnaud Marchant and Tessa Goetghebuer and Martin O. C. Ota and Ingrid Wolfe and Serign Jawo Ceesay and Donat de Groote and Tumani Corrah and Steve Bennett and J Wheeler and Kris Huygen and Peter Aaby and Keith P. W. J. McAdam and Melanie J. Newport},
  journal={Journal of immunology},
  year={1999},
  volume={163 4},
  pages={
          2249-55
        }
}
Data obtained in animals indicate that neonatal immune responses are biased toward Th2. This could reduce the efficacy of vaccines against viral and mycobacterial diseases. The ability of human newborns to develop a Th1 immune response upon immunization has not been studied. Since the vaccine Mycobacterium bovis bacillus Calmette-Guérin (BCG) triggers a Th1-type response in adults, we investigated whether it induces a similar response in newborns and whether age at vaccination influences… Expand
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