Newborn Rabbit Blood–Brain Barrier Is Selectively Permeable and Differs Substantially from the Adult

@article{Braun1980NewbornRB,
  title={Newborn Rabbit Blood–Brain Barrier Is Selectively Permeable and Differs Substantially from the Adult},
  author={Leon D. Braun and Eain M. Cornford and William H. Oldendorf},
  journal={Journal of Neurochemistry},
  year={1980},
  volume={34}
}
Abstract: Examination of blood‐brain barrier (BBB) function by the intracarotid injection technique has been utilized in studies of newborn (6–30 h) and adult rabbits. The exclusion of mannitol (mol. wt. 182), dextran (mol. wt. 60,000–90,000) and indium‐bound EDTA indicate that the newborn BBB has restrictive properties similar to the adult. At birth, saturable, carrier‐mediated transport mechanisms are present, regulating the entry of glucose, amino acids, organic acids, purines, nucleosides… 
Comparison of lipid-mediated blood-brain-barrier penetrability in neonates and adults.
TLDR
The similarities in slope-intercept relationships indicate that newborn rabbit and adult rat brain endothelia are functionally similar with respect to lipid-mediated permeability [in contrast to previous studies that have established dramatic differences in selective permeabilities of metabolites transported by saturable, carrier-mediated ("facilitated diffusion") mechanisms].
Developmental Modulations of Blood-Brain Barrier Permeability as an Indicator of Changing Nutritional Requirements in the Brain
TLDR
The present study indicates that the inclusion of these metabolites (adenine, arginine, choline, tryptophan and monocarboxylic acids such as lactate) would be beneficial in clinical intravenous feeding of the neonate, to meet the apparent needs of the developing central nervous system.
Developmental modulation of blood-brain-barrier glucose transport in the rabbit
TLDR
Developmental up-regulation of the rabbit BBB glucose transporter is characterized by no changes in transporter affinity, and the first demonstration of increased membrane transporter proteins correlating with an age-related increase in glucose transporter maximal velocity is provided.
Kinetics of Neutral Amino Acid Transport Through the Blood‐Brain Barrier of the Newborn Rabbit
TLDR
Under conditions of high plasma amino acids, the increased capacity of the newborn transport system allows for a higher rate of amino acid transport into brain than would occur via the lower capacity system present in the adult rat brain.
Developmental changes of l-arginine transport at the blood-brain barrier in rats.
TLDR
The hypothesis that elevation of blood-to-brain l-arginine transport across the blood-brain barrier in the postnatal period coincides with up-regulation of cationic acid transporter 1 (CAT1) expression in developing brain capillaries is tested is supported and suggests that the supply ofBlood-born l- arginine to the brain via CAT1 at the BBB plays a key role in meeting the elevated demand for l- Argentine in postnatal brain.
Physiology and molecular biology of barrier mechanisms in the fetal and neonatal brain
TLDR
The alternative hypothesis that the barrier mechanisms in developing brain are likely to be appropriately matched to each stage of its development is suggested, suggesting future directions this field could follow with special emphasis on potential applications in a clinical setting.
Early ultrastructural changes in blood-brain barrier vessels of the rat embryo.
TLDR
It is found that fenestrations, that are frequent at E11, declined rapidly and were last seen at E13 in intraparenchymal vessels and at E17 in pial vessels, suggesting that intimate contact between neural tissue and vessel walls is not a requirement for BBB expression.
Enhanced Insulin Binding to Blood-Brain Barrier In Vivo and to Brain Microvessels In Vitro in Newborn Rabbits
TLDR
The increased availability of circulating insulin to the newborn brain was further corroborated by elevated CSF/serums and brain/serum insulin ratios in the newborn versus adult, suggesting that insulin has increased access to the new born brain where it may function as a growth factor.
Regional Kinetic Constants for Blood–Brain Barrier Pyruvic Acid Transport in Conscious Rats by the Monocarboxylic Acid Carrier
Abstract: The present investigation using labeled pyruvate describes the regional distribution and kinetics of the monocarboxylic acid carrier at the blood–brain barrier of conscious rats. The
Limited Blood‐Brain Barrier Transport of Polyamines
TLDR
Transport of polyamines across the blood‐brain barrier of adult rats was examined by measuring the amount of radioactivity that reached the forebrain 5 s after a “bolus’ intracarotid injection”, which indicated that putrescine does not interact with carriers for adenosine, arginine, choline, or leucine.
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