New ways in RGD-peptide mediated drug targeting to angiogenic endothelium

  title={New ways in RGD-peptide mediated drug targeting to angiogenic endothelium},
  author={Kai Temming and Damon L. Meyer and Roger Zabiniski and Peter D. Senter and Grietje Molema and Klaas Poelstra and Robbert Jan Kok},
During the past decade, RGD-peptides have become a popular tool for the targeting of drugs and imaging agents to αvβ3-integring expressing tumor vasculature. RGD-peptides have been introduced by recombinant means into therapeutic proteins and viruses. Chemical means have been applied to couple RGD-peptides and RGD-mimetics to liposomes, polymers, peptides, small molecule drugs and radiotracers. Some of these products show impressive results in preclinical animal models and a RGD targeted… CONTINUE READING


Publications referenced by this paper.

Delivery of kinase inhibitors and antimitotic agents into angiogenic endothelium using RGD - equipped macromolecular carriers

  • K. Temming, M. Lacombe, +4 authors G. Molema
  • 2007

New RGD - equipped RGD - albumin carrier molecules for specific targeting of the VEGF kinase inhibitor PTK 787 to angiogenic vasculature

  • K. Temming, M. Lacombe, +5 authors R. J. Kok
  • 2006

Similar Papers

Loading similar papers…