New verticilides, inhibitors of acyl-CoA:cholesterol acyltransferase, produced by Verticillium sp. FKI-2679

Abstract

Verticillium sp. FKI-2679, a soil isolate, was found to produce inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT) in a cell-based assay using ACAT1- and ACAT2-expressing CHO cells. Three new compounds, verticilides A2, A3 and B1, were isolated along with a known compound, verticilide A1, from the fermentation broth of the fungus by solvent… (More)
DOI: 10.1038/ja.2012.12

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@article{Ohshiro2012NewVI, title={New verticilides, inhibitors of acyl-CoA:cholesterol acyltransferase, produced by Verticillium sp. FKI-2679}, author={Taichi Ohshiro and Daisuke Matsuda and Takeuchi Kazuhiro and Ryuji Uchida and Kenichi Nonaka and Rokuro Masuma and Hiroshi Tomoda}, journal={The Journal of Antibiotics}, year={2012}, volume={65}, pages={255-262} }