New urushiols with platelet aggregation inhibitory activities from resin of Toxicodendron vernicifluum.

@article{Xie2016NewUW,
  title={New urushiols with platelet aggregation inhibitory activities from resin of Toxicodendron vernicifluum.},
  author={Ya Xie and Jie Zhang and Wenyuan Liu and Ning Xie and Feng Feng and Wei Qu},
  journal={Fitoterapia},
  year={2016},
  volume={112},
  pages={38-44}
}
Eight new urushiol-type compounds (1-7b), along with seven known compounds were isolated from the resin of Toxicodendron vernicifluum Stokes. Their structures were determined by extensive spectroscopic methods, included (1)H NMR, (13)C NMR, HMQC, HMBC, HRESIMS, EI-MS in combination with CD methods. All the compounds except 7a and 7b were evaluated for their anti-platelet aggregation activities in vitro. Among them, compound 5 (IC50=5.12±0.85μmol/L), with a vic-diol moiety in the long alkyl… CONTINUE READING

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