New treatment options for panic disorder: clinical trials from 2000 to 2010
@article{Freire2011NewTO, title={New treatment options for panic disorder: clinical trials from 2000 to 2010}, author={Rafael Christophe Freire and Jaime E.C. Hallak and Jos{\'e} A. S. Crippa and Ant{\^o}nio Eg{\'i}dio Nardi}, journal={Expert Opinion on Pharmacotherapy}, year={2011}, volume={12}, pages={1419 - 1428} }
Introduction: Panic disorder (PD) is a prevalent psychiatric disorder characterized by unexpected and recurrent panic attacks. PD patients present significant psychosocial impairment and a high risk of psychiatric comorbidities and suicide. PD should be treated effectively as soon as the symptoms emerge because the longer these patients remain without treatment, the worse the prognosis will be. Areas covered: The authors carried out a systematic review of the literature regarding the…
30 Citations
Pharmacological Therapy in Panic Disorder: Current Guidelines and Novel Drugs Discovery for Treatment-resistant Patient
- Psychology, MedicineClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology
- 2019
The importance of immediate and proper treatment, the gap in the current management of PD with special emphasis on pharmacotherapy, and evidence regarding the novel anti-panic drugs including the drugs in developments such as metabotropic glutamate (mGlu 2/3) agonist and levetiracetam are covered.
Risks and benefits of medications for panic disorder: a comparison of SSRIs and benzodiazepines
- Psychology, MedicineExpert opinion on drug safety
- 2018
Despite strong evidence of the effectiveness of SSRIs and benzodiazepines in the treatment of PD, few trials have performed head-to-head comparisons of these two drug classes, which could help improve the evidence-based pharmacotherapy of PD.
ANTIDEPRESSANTS AND PANIC DISORDER
- Psychology, Medicine
- 2012
Comparison studies of antidepressants currently used for the treatment of panic disorder suggest selective serotonin reuptake inhibitors and venlafaxine should be considered as first line agents because their clinical efficacy is as high as those observed with other classes of antidepressants but they are associated with a significantly lower likelihood of side effects.
Latency to selective serotonin reuptake inhibitor vs benzodiazepine treatment in patients with panic disorder: a naturalistic study.
- Medicine, PsychologyCNS spectrums
- 2021
A substantial delay in implementing adequate pharmacological treatments in patients with PD is confirmed, and the discrepancy between recommendations from international treatment guidelines and common clinical practice in relation to BDZ prescription is highlighted.
Pharmacological Treatment of Panic Disorder with Non-Selective Drugs
- Psychology, Medicine
- 2016
It is important to use existing scientific evidences regarding effectiveness, tolerability and safety, combined with clinical experience, to plan a rational treatment sequence for panic disorder patients.
Emerging drugs for panic disorder
- Biology, MedicineExpert opinion on emerging drugs
- 2011
Defining biomarkers and endophenotypes in PD may offer advantages in both understanding the pathophysiology of the disorder and selecting appropriate targets and outcomes for planning future pharmacological research.
Treatment–resistant panic disorder: a systematic review
- Psychology, MedicineExpert opinion on pharmacotherapy
- 2016
Augmentation of the pharmacological treatment with cognitive-behavioral therapy demonstrated some short-term efficacy in treatment–resistant PD, and preliminary evidences of efficacy for monotherapy with reboxetine and olanzapine, and augmentation with pindolol, divalproex sodium, aripiprazole and OlanzAPine in short- term treatment.
Newer antidepressants and panic disorder: a meta-analysis
- Psychology, MedicineInternational clinical psychopharmacology
- 2013
The following antidepressants were significantly superior to placebo for PD patients with the following increasing order of effectiveness: citalopram, sertraline, paroxetine, fluoxetines, and venlafaxine for panic symptoms and paroxETine,fluoxetne, fluvoxetus, and mirtazapine for overall anxiety symptoms.
Current pharmacological interventions in panic disorder.
- Psychology, MedicineCNS & neurological disorders drug targets
- 2014
Recent data indicate that augmentation strategies with aripiprazole, olanzapine, pindolol or clonazepam may be effective and D-cycloserine is a promising agent in the augmentation of cognitive behavioral therapy.
Pharmacological and Neuromodulatory Treatments for Panic Disorder: Clinical Trials from 2010 to 2018
- Psychology, MedicinePsychiatry investigation
- 2019
The efficacy of tranylcypromine, paroxetine, clonazepam, alprazolam and escitalopram is confirmed, and vortioxetine and TMS, with duration of 4 or more weeks, also seems to be effective.
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