New total synthesis of niphatesine C and norniphatesine C based on a Sonogashira reaction.


The pyridine alkaloid niphatesine C and its analogue norniphatesine C were prepared in a short and efficient way starting from commercially available 3-iodopyridine and undec-10-yn-1-ol using a Sonogashira reaction as the key step. The resulting alkylpyridines were tested for antimicrobial activity against several bacteria and fungi. The cytotoxic… (More)