New tools to study the role of B cells in cytomegalovirus infections

  title={New tools to study the role of B cells in cytomegalovirus infections},
  author={Ari Waisman and Andrew L Croxford and Filiz Demircik},
  journal={Medical Microbiology and Immunology},
B cells were previously shown to mediate partial protection against CMV infection, as in the absence of B cells, latently infected mice were more susceptible to virus reactivation. It remains unclear if this effect stems from the loss of B cells as antibody producers or as antigen presenting cells. To address this fundamental question, we propose to make use of new mouse models that allow conditional ablation of B cells or that allow for the generation of mice with B cells that are not able to… CONTINUE READING

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