New therapy via targeting androgen receptor in monocytes/macrophages to battle atherosclerosis.

@article{Huang2014NewTV,
  title={New therapy via targeting androgen receptor in monocytes/macrophages to battle atherosclerosis.},
  author={Chiung-Kuei Huang and Haiyan Pang and Lin Lin Wang and Yuanjie Niu and Jie Luo and Eugene Chang and Janet D. Sparks and Soo Ok Lee and Chawnshang Chang},
  journal={Hypertension},
  year={2014},
  volume={63 6},
  pages={1345-53}
}
The male sex has a higher risk to develop coronary artery diseases, including atherosclerosis. The androgen receptor (AR) is expressed in several atherosclerosis-associated cell types, including monocytes/macrophages, endothelial cells (ECs), and smooth muscle cells (SMCs), but its pathophysiological role in each cell type during the development of atherosclerotic lesions remains unclear. Using the Cre-loxP system, we selectively knocked out AR in these 3 cell types and the resultant AR… CONTINUE READING
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