New therapy targeting differential androgen receptor signaling in prostate cancer stem/progenitor vs. non-stem/progenitor cells.

@article{Lee2013NewTT,
  title={New therapy targeting differential androgen receptor signaling in prostate cancer stem/progenitor vs. non-stem/progenitor cells.},
  author={S. Lee and Zhifang Ma and Chiuan-Ren Yeh and J. Luo and Tzu-hua Lin and K. Lai and S. Yamashita and L. Liang and J. Tian and L. Li and Q. Jiang and Chiung-Kuei Huang and Y. Niu and S. Yeh and C. Chang},
  journal={Journal of molecular cell biology},
  year={2013},
  volume={5 1},
  pages={
          14-26
        }
}
The androgen deprivation therapy (ADT) to systematically suppress/reduce androgens binding to the androgen receptor (AR) has been the standard therapy for prostate cancer (PCa); yet, most of ADT eventually fails leading to the recurrence of castration resistant PCa. Here, we found that the PCa patients who received ADT had increased PCa stem/progenitor cell population. The addition of the anti-androgen, Casodex, or AR-siRNA in various PCa cells led to increased stem/progenitor cells, whereas… Expand
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