New therapeutical indications of ursodeoxycholic acid.

  title={New therapeutical indications of ursodeoxycholic acid.},
  author={Ionel Copaci and Laurenţiu Micu and Laura Iliescu and Mihai Voiculescu},
  journal={Romanian journal of gastroenterology},
  volume={14 3},
Until the 1980s the role of bile acids in the initiation of liver injury in man was only suspected on the basis of the toxicity of whole bile and bile salts, and of studies showing elevations in serum and tissue levels of bile salts in liver diseases. The beneficial effects of ursodeoxycholic acid (UDCA) in primary biliary cirrhosis have provided the first firm evidence that bile acids may in some way be related to injury in man. There are many questions regarding the hepato-protective effect… CONTINUE READING


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Functional characterization of the phosphorylation of the bile salt export pump by protein kinase

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  • C. Hepatology
  • 2001
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