New therapeutic frontiers for metabotropic glutamate receptors.

  title={New therapeutic frontiers for metabotropic glutamate receptors.},
  author={Colleen M Niswender and Carrie K Jones and P Jeffrey Conn},
  journal={Current topics in medicinal chemistry},
  volume={5 9},
Our understanding of glutamatergic transmission in the central nervous system has been greatly expanded with the discovery and investigation of the metabotropic glutamate receptor family. Complementing the ionotropic glutamate-gated ion channels, these G-protein coupled receptors play critical roles in neuronal and glial functions such as the modulation of neuronal excitability, synaptic transmission, and various metabolic functions. Because of the ubiquitous distribution of glutamatergic… CONTINUE READING


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