New therapeutic approaches to treat medullary thyroid carcinoma
@article{Schlumberger2008NewTA, title={New therapeutic approaches to treat medullary thyroid carcinoma}, author={Martin Schlumberger and Francesca Carlomagno and Eric Baudin and Jean Michel Bidart and Massimo Santoro}, journal={Nature Clinical Practice Endocrinology \&Metabolism}, year={2008}, volume={4}, pages={22-32} }
Medullary thyroid carcinoma (MTC) accounts for up to 8% of all thyroid cancers. Although primary surgery is curative in the vast majority of patients treated at an early stage, disease can persist or recur with deleterious effects on quality of life. Local and distant metastases can occur and are the major causes of mortality. Reoperation, embolization, and perhaps radiotherapy can improve the outcome for some patients who are not cured by primary surgery, but there is a need for novel…
184 Citations
2012 European Thyroid Association Guidelines for Metastatic Medullary Thyroid Cancer
- Medicine, BiologyEuropean Thyroid Journal
- 2012
These 21 recommendations focus on MTC patients with distant metastases and a detailed follow-up protocol of patients with biochemical or imaging evidence of disease, selection criteria for treatment, and treatment modalities, including local and systemic treatments based on the results of recent trials.
Management of Patients with Metastatic Medullary Thyroid Carcinoma: The Role for Systemic Therapy
- Medicine, Biology
- 2016
This chapter outlines a suggested approach to the use of systemic therapy in progressive metastatic MTC, which is a relative rarity of this tumor and the infrequent need for systemic therapy.
Alternative therapeutic approaches in the treatment of primary and secondary dedifferentiated and medullary thyroid carcinoma.
- Medicine, BiologySeminars in nuclear medicine
- 2011
I-meta-iodobenzylguanidine therapy is a noteworthy therapeutic approach in patients experiencing metastasized medullary thyroid carcinoma, raising the hope for better outcomes in these patients in future.
European Thyroid Association Guidelines for Metastatic Medullary Thyroid Cancer
- Medicine
- 2012
These 21 recommendations focus on MTC patients with distant metastases and a detailed follow-up protocol of patients with biochemical or imaging evidence of disease, selection criteria for treatment, and treatment modalities, including local and systemic treatments based on the results of recent trials.
Putative BRAF activating fusion in a medullary thyroid cancer
- Biology, MedicineCold Spring Harbor molecular case studies
- 2016
The genomic profiles of two medullary thyroid cancers are described and the presence of a putative oncogenic BRAF fusion in one is reported and such alterations, previously observed in other malignancies and known targets of available drugs, can benefit patients who currently have no treatment options.
RET therapeutic targeting in medullary thyroid carcinoma: molecular mechanisms of resistance
- Biology, Medicine
- 2015
Gain of MAPK cascade signaling seems to be able to mediate escape from RET inibition in vitro, thus suggesting p90RSK as a promising molecular target to overcome resistance formation to RET TKIs.
Molecular genetics of medullary thyroid carcinoma: the quest for novel therapeutic targets.
- Biology, MedicineJournal of molecular endocrinology
- 2009
The data on the involvement of genes acting in the RET and RB1/TP53 pathways in MTC is reviewed, with a view to improving the efficacy of RET-targeted therapies.
Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer.
- Medicine, BiologyJournal of clinical oncology : official journal of the American Society of Clinical Oncology
- 2010
It is demonstrated that vandetanib may provide an effective therapeutic option in patients with advanced hereditary MTC, a rare disease for which there has been no effective therapy.
Pretargeted radioimmunotherapy in the treatment of metastatic medullary thyroid cancer
- Medicine, BiologyCurrent oncology
- 2009
The most appropriate prognostic indicators and the most efficient imaging techniques for the selection of patients intended to be treated with pretargeted radioimmunotherapy (pRIT) are considered and the effectiveness and toxicity of this new therapeutic modality is analyzed.
References
SHOWING 1-10 OF 68 REFERENCES
A phase II trial of imatinib therapy for metastatic medullary thyroid carcinoma.
- MedicineThe Journal of clinical endocrinology and metabolism
- 2007
Imatinib therapy yielded no objective responses and induced considerable toxicity in patients with MTC, and patients with supplemented hypothyroidism or with recurrent nerve palsy are specifically at risk for serious adverse events and need special attention when treated with imatinib.
Vandetanib in metastatic hereditary medullary thyroid cancer: Follow-up results of an open-label phase II trial
- Medicine, Biology
- 2007
Vandetanib (ZD6474) is a once- daily oral oral agent that selectively targets RET, VEGFR and EGFR tyrosine kinases that are likely to contribute to tumor growth and metastasis in patients with hereditary thyroid cancer.
Chemoembolization for liver metastases from medullary thyroid carcinoma.
- MedicineThe Journal of clinical endocrinology and metabolism
- 2006
TACE should be considered for treating MTC patients with progressive and predominant liver metastasis, and preferably at an early stage during the course of metastatic disease.
Efficacy of imatinib mesylate in advanced medullary thyroid carcinoma.
- Medicine, BiologyEuropean journal of endocrinology
- 2007
Imatinib mesylate is well tolerated, no tumour remission was observed, only transient stable disease was achieved in some patients with advanced MTC, and the median duration of therapy was 8 months.
Treatment of advanced medullary thyroid carcinoma with a combination of cyclophosphamide, vincristine, and dacarbazine
- MedicineCancer
- 1994
On the basis of the activity of cyclophosphamide, vincristine, and dacarbazine in other advanced neuroendocrine neoplasms, the authors tested the combination in patients with advanced MTC.
Apoptotic cell death induction and angiogenesis inhibition in large established medullary thyroid carcinoma xenografts by Ret inhibitor RPI-1.
- Biology, MedicineBiochemical pharmacology
- 2006
Selective arterial chemoembolization for hepatic metastases from medullary thyroid carcinoma.
- MedicineSurgery
- 2005
Survival improvement in patients with medullary thyroid carcinoma who undergo pretargeted anti-carcinoembryonic-antigen radioimmunotherapy: a collaborative study with the French Endocrine Tumor Group.
- Medicine, BiologyJournal of clinical oncology : official journal of the American Society of Clinical Oncology
- 2006
PURPOSE
No effective therapy is currently available for the management of patients with metastatic medullary thyroid carcinoma (MTC). The efficacy of pretargeted radioimmunotherapy (pRAIT) with…
Medullary thyroid cancer: analyses of survival and prognostic factors and the role of radiation therapy in local control.
- MedicineThyroid : official journal of the American Thyroid Association
- 1996
There was no difference in local/regional relapse free rate between patients receiving external radiation and those that did not, but in 40 high risk patients (microscopic residual disease, extraglandular invasion, or lymph node involvement), the local/Regional relapsefree rate was 86% at 10 years with postoperative external beam radiation.
Mechanisms of Disease: cancer targeting and the impact of oncogenic RET for medullary thyroid carcinoma therapy
- Medicine, BiologyNature Clinical Practice Oncology
- 2006
It becomes strikingly obvious that inhibition of RET oncogene function can be a viable option for the treatment of MTC.