New therapeutic agents in the management of hypertension: angiotensin II-receptor antagonists and renin inhibitors.

Abstract

OBJECTIVE To review the chemistry, pharmacokinetics, and clinical trials of two new classes of antihypertensive drugs, angiotensin II-receptor antagonists and renin inhibitors. DATA SOURCES Primary literature on angiotensin II-receptor antagonists and renin inhibitors was identified through a comprehensive medical literature search from 1961 through 1993… (More)

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