New techniques for imaging, digitization and analysis of three-dimensional neural morphology on multiple scales.

@article{Wearne2005NewTF,
  title={New techniques for imaging, digitization and analysis of three-dimensional neural morphology on multiple scales.},
  author={Susan L. Wearne and Alfredo Rodriguez and Douglas B. Ehlenberger and Anne B. Rocher and S. Christine Henderson and Patrick R. Hof},
  journal={Neuroscience},
  year={2005},
  volume={136 3},
  pages={661-80}
}
Cognitive impairment in normal aging and neurodegenerative diseases is accompanied by altered morphologies on multiple scales. Understanding of the role of these structural changes in producing functional deficits in brain aging and neuropsychiatric disorders requires accurate three-dimensional representations of neuronal morphology, and realistic biophysical modeling that can directly relate structural changes to altered neuronal firing patterns. To date however, tools capable of resolving… CONTINUE READING
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