New targets of β-catenin signaling in the liver are involved in the glutamine metabolism

  title={New targets of β-catenin signaling in the liver are involved in the glutamine metabolism},
  author={A. Cadoret and C. Ovejero and B. Terris and E. Souil and L. L{\'e}vy and W. Lamers and J. Kitajewski and A. Kahn and C. Perret},
  • A. Cadoret, C. Ovejero, +6 authors C. Perret
  • Published 2002
  • Medicine, Biology
  • Oncogene
  • Inappropriate activation of the Wnt/β-catenin signaling has been implicated in the development of hepatocellular carcinoma (HCC), but exactly how β-catenin works remains to be elucidated. To identify, in vivo, the target genes of β-catenin in the liver, we have used the suppression subtractive hybridization technique and transgenic mice expressing an activated β-catenin in the liver that developed hepatomegaly. We identified three genes involved in glutamine metabolism, encoding glutamine… CONTINUE READING
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