New targets of β-catenin signaling in the liver are involved in the glutamine metabolism

@article{Cadoret2002NewTO,
  title={New targets of β-catenin signaling in the liver are involved in the glutamine metabolism},
  author={Axelle Cadoret and Christine Ovejero and Beno{\^i}t Terris and Evelyne Souil and Laurence L{\'e}vy and Wouter H. Lamers and Jan E Kitajewski and A. K. Azad Kahn and Christine Perret},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={8293-8301}
}
Inappropriate activation of the Wnt/β-catenin signaling has been implicated in the development of hepatocellular carcinoma (HCC), but exactly how β-catenin works remains to be elucidated. To identify, in vivo, the target genes of β-catenin in the liver, we have used the suppression subtractive hybridization technique and transgenic mice expressing an activated β-catenin in the liver that developed hepatomegaly. We identified three genes involved in glutamine metabolism, encoding glutamine… CONTINUE READING
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