New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents.

@article{RoldnPea2017NewTD,
  title={New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents.},
  author={Jes{\'u}s M Rold{\'a}n-Pe{\~n}a and Daniel Alejandre-Ramos and {\'O}scar L{\'o}pez and In{\'e}s Maya and Irene Lagunes and Jos{\'e} M. Padr{\'o}n and Luis Emiliano Pe{\~n}a-Altamira and Manuela Bartolini and Barbara Monti and Maria Laura Bolognesi and Jos{\'e} G. Fern{\'a}ndez-Bola{\~n}os},
  journal={European journal of medicinal chemistry},
  year={2017},
  volume={138},
  pages={761-773}
}
We have designed a series of tacrine-based homo- and heterodimers that incorporate an antioxidant tether (selenoureido, chalcogenide) as new dual compounds: for the treatment of Alzheimer's disease and as antiproliferative agents. Symmetrical homodimers bearing a dichalcogenide or selenide-based tether, the best compounds in the series, were found to be strong and highly selective electric eel AChE inhibitors, with inhibition constants within the low nanomolar range. This high inhibitory… CONTINUE READING