New synthetic inhibitors of microtubule depolymerization.

  title={New synthetic inhibitors of microtubule depolymerization.},
  author={Ulrich Klar and Heidemarie Graf and Olaf Schenk and Bob Roehr and Henk Schulz},
  journal={Bioorganic & medicinal chemistry letters},
  volume={8 11},
A new class of borneol esters that might be considered as biological analogs of paclitaxel regarding their action on microtubules has been found. By structure-activity optimizations, compounds stabilizing microtubules much better than paclitaxel while showing a remarkably reduced cytotoxic activity were obtained. This dissoziation will open completely new therapeutic areas.