New synthesis of a stereoisomeric mixture of methyl 12-trishomofarnesoate, a juvenile hormone mimic useful in sericulture by increasing silk production.

  • Kenji Mori
  • Published 2017 in
    Proceedings of the Japan Academy. Series B…

Abstract

A mixture of (E,Z)-isomers of methyl 12-trishomofarnesoate (methyl 3,7,11-trimethyl-2,6,10-pentadecatrienoate), a juvenile hormone mimic, was synthesized in nine steps (32.6% overall yield) by starting from only four commercially available materials: 2-hexanone, vinylmagnesium bromide, methyl acetoacetate and trimethyl phosphonoacetate. The mimic is useful in increasing the yield of silk by elongating the larval period of the silkworm, Bombyx mori (L.).

DOI: 10.2183/pjab.93.041

Cite this paper

@article{Mori2017NewSO, title={New synthesis of a stereoisomeric mixture of methyl 12-trishomofarnesoate, a juvenile hormone mimic useful in sericulture by increasing silk production.}, author={Kenji Mori}, journal={Proceedings of the Japan Academy. Series B, Physical and biological sciences}, year={2017}, volume={93 8}, pages={648-655} }