New studies on the heat resistance of hamster-adapted scrapie agent: threshold survival after ashing at 600 degrees C suggests an inorganic template of replication.

@article{Brown2000NewSO,
  title={New studies on the heat resistance of hamster-adapted scrapie agent: threshold survival after ashing at 600 degrees C suggests an inorganic template of replication.},
  author={Paul C Brown and Edward H Rau and Bruce K Johnson and Alfred E Bacote and Clarence J. Gibbs and D. Carleton Gajdusek},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 7},
  pages={3418-21}
}
One-gram samples from a pool of crude brain tissue from hamsters infected with the 263K strain of hamster-adapted scrapie agent were placed in covered quartz-glass crucibles and exposed for either 5 or 15 min to dry heat at temperatures ranging from 150 degrees C to 1,000 degrees C. Residual infectivity in the treated samples was assayed by the intracerebral inoculation of dilution series into healthy weanling hamsters, which were observed for 10 months; disease transmissions were verified by… CONTINUE READING

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