New structural insights into the inhibition of serine proteases by cyclic peptides from bacteria.

@article{McDonough2003NewSI,
  title={New structural insights into the inhibition of serine proteases by cyclic peptides from bacteria.},
  author={M. McDonough and C. Schofield},
  journal={Chemistry & biology},
  year={2003},
  volume={10 10},
  pages={
          898-900
        }
}
  • M. McDonough, C. Schofield
  • Published 2003
  • Medicine, Biology
  • Chemistry & biology
  • The inhibition of enzymes employing a nucleophilic serine residue by natural products has been studied for many years. More recently, high-resolution structural analyses have begun to augment kinetic analyses. In this issue of Chemistry & Biology, Schulz and colleagues describe the crystal structure of scyptolin A, a cyclic peptide produced by cyanobacteria, complexed with elastase. Together with structures for a related inhibitor bound to trypsin, the work may assist in the design of… CONTINUE READING
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