New structural insight of C-terminal region of Syntenin-1, enhancing the molecular dimerization and inhibitory function related on Syndecan-4 signaling

Abstract

The PDZ domain-containing scaffold protein, syntenin-1, binds to the transmembrane proteoglycan, syndecan-4, but the molecular mechanism/function of this interaction are unknown. Crystal structure analysis of syntenin-1/syndecan-4 cytoplasmic domains revealed that syntenin-1 forms a symmetrical pair of dimers anchored by a syndecan-4 dimer. The syndecan-4… (More)
DOI: 10.1038/srep36818

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Cite this paper

@inproceedings{Choi2016NewSI, title={New structural insight of C-terminal region of Syntenin-1, enhancing the molecular dimerization and inhibitory function related on Syndecan-4 signaling}, author={Youngsil Choi and Ji-Hye Yun and Jiho Yoo and Inhwan Lee and Heeyoun Kim and Hye-Nam Son and I. Kim and Ho Sup Yoon and Pascale Zimmermann and John Robert Couchman and Hyun-soo Cho and Eok-Soo Oh and Weontae Lee}, booktitle={Scientific reports}, year={2016} }