New striatal dopamine neurons in MPTP-treated macaques result from a phenotypic shift and not neurogenesis.

@article{Tand2006NewSD,
  title={New striatal dopamine neurons in MPTP-treated macaques result from a phenotypic shift and not neurogenesis.},
  author={D. Tand{\'e} and G{\"u}nter U. H{\"o}glinger and Thomas Debeir and Nils Freundlieb and Etienne C. Hirsch and Chantal François},
  journal={Brain : a journal of neurology},
  year={2006},
  volume={129 Pt 5},
  pages={1194-200}
}
We investigated whether there is neurogenesis in the striatum of aged monkeys, and whether dopamine (DA) depletion induces the genesis of new DA neurons in this structure. Six aged macaques received repeated intraperitoneal injections of bromodeoxyuridine (BrdU) over a 3 week period to label dividing cells. Three macaques were injected in parallel with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to decrease dopaminergic innervation of the striatum. The brains were… CONTINUE READING
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