New strategy to surface functionalization of polymeric nanoparticles: one-pot synthesis of scFv anti-LDL(−)-functionalized nanocapsules

@article{Bender2014NewST,
  title={New strategy to surface functionalization of polymeric nanoparticles: one-pot synthesis of scFv anti-LDL(−)-functionalized nanocapsules},
  author={Eduardo Andr{\'e} Bender and Marcela Frota Cavalcante and M{\'a}rcia Duarte Adorne and Let{\'i}cia Marques Colom{\'e} and S{\'i}lvia Stanisçuaski Guterres and Dulcineia Saes Parra Abdalla and Adriana Raffin Pohlmann},
  journal={Pharmaceutical Research},
  year={2014},
  volume={31},
  pages={2975-2987}
}
In general, the surface functionalization of polymeric nanoparticles is carried out by covalently bounding ligands to the nanoparticle surface. This process can cause a lack or decrease of the ligand specificity to its target receptor, besides the need of purification steps. We proposed a ligand-metal-chitosan-lecithin complex as a new strategy to functionalize the surface of biodegradable nanoparticles. One pot synthesis of scFv anti-LDL(−)-functionalized nanocapsules was carried out by self… CONTINUE READING

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