New strategy of tacrolimus administration in animal model based on tacrolimus-loaded microspheres.

  title={New strategy of tacrolimus administration in animal model based on tacrolimus-loaded microspheres.},
  author={J. J. Zamorano-Le{\'o}n and In{\'e}s Hern{\'a}ndez-Fisac and Sandra Guerrero and J. Tamarit-Rodriguez and J. Santos-Sancho and B. Sope{\~n}a and G. Escolar and I. L{\'o}pez-V{\'i}lchez and J. Duarte and A. Barrientos and A. J. L{\'o}pez-Farr{\'e}},
  journal={Transplant immunology},
  • J. J. Zamorano-León, Inés Hernández-Fisac, +8 authors A. J. López-Farré
  • Published 2016
  • Medicine
  • Transplant immunology
  • New strategies for tacrolimus administration that conserve its immunosuppressive effect but avoiding fluctuations in tacrolimus circulating levels are needed. The aim was to analyze if subcutaneous biodegradable tacrolimus-loaded microspheres injection promoted a significant immunosuppressive response in rats. Rats received two subcutaneous tacrolimus-loaded microspheres injections at different days, the first injection was done at day 0 and the second injection was done 12 days after. Plasma… CONTINUE READING
    3 Citations


    Pharmacokinetic and immunosuppressive effects of tacrolimus‐loaded biodegradable microspheres
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