• DOI:10.1016/j.trim.2016.04.004
Corpus ID: 25945336

New strategy of tacrolimus administration in animal model based on tacrolimus-loaded microspheres.

@article{ZamoranoLen2016NewSO,
  title={New strategy of tacrolimus administration in animal model based on tacrolimus-loaded microspheres.},
  author={J. J. Zamorano-Le{\'o}n and In{\'e}s Hern{\'a}ndez-Fisac and Sandra Guerrero and J. Tamarit-Rodriguez and J. Santos-Sancho and B. Sope{\~n}a and G. Escolar and I. L{\'o}pez-V{\'i}lchez and J. Duarte and A. Barrientos and A. J. L{\'o}pez-Farr{\'e}},
  journal={Transplant immunology},
  year={2016},
  volume={36},
  pages={
          9-13
        }
}

J. J. Zamorano-León, Inés Hernández-Fisac, +8 authors A. J. López-Farré

Published 2016

Medicine

Transplant immunology

New strategies for tacrolimus administration that conserve its immunosuppressive effect but avoiding fluctuations in tacrolimus circulating levels are needed. The aim was to analyze if subcutaneous biodegradable tacrolimus-loaded microspheres injection promoted a significant immunosuppressive response in rats. Rats received two subcutaneous tacrolimus-loaded microspheres injections at different days, the first injection was done at day 0 and the second injection was done 12 days after. Plasma… CONTINUE READING

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