New strategy of tacrolimus administration in animal model based on tacrolimus-loaded microspheres.

@article{ZamoranoLen2016NewSO,
  title={New strategy of tacrolimus administration in animal model based on tacrolimus-loaded microspheres.},
  author={J. J. Zamorano-Le{\'o}n and In{\'e}s Hern{\'a}ndez-Fisac and Sandra Guerrero and J. Tamarit-Rodriguez and J. Santos-Sancho and B. Sope{\~n}a and G. Escolar and I. L{\'o}pez-V{\'i}lchez and J. Duarte and A. Barrientos and A. J. L{\'o}pez-Farr{\'e}},
  journal={Transplant immunology},
  year={2016},
  volume={36},
  pages={
          9-13
        }
}
  • J. J. Zamorano-León, Inés Hernández-Fisac, +8 authors A. J. López-Farré
  • Published 2016
  • Medicine
  • Transplant immunology
  • New strategies for tacrolimus administration that conserve its immunosuppressive effect but avoiding fluctuations in tacrolimus circulating levels are needed. The aim was to analyze if subcutaneous biodegradable tacrolimus-loaded microspheres injection promoted a significant immunosuppressive response in rats. Rats received two subcutaneous tacrolimus-loaded microspheres injections at different days, the first injection was done at day 0 and the second injection was done 12 days after. Plasma… CONTINUE READING
    3 Citations

    References

    SHOWING 1-10 OF 32 REFERENCES
    Pharmacokinetic and immunosuppressive effects of tacrolimus‐loaded biodegradable microspheres
    • Yasunori Miyamoto, T. Uno, +6 authors H. Kawarasaki
    • Medicine
    • Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
    • 2004
    • 18
    Clinical Pharmacokinetics of Tacrolimus
    • 626
    Tacrolimus whole blood concentrations correlate closely to side-effects in renal transplant recipients.
    • 126
    Nephrotoxic effects of primary immunosuppression with FK-506 and cyclosporine regimens after liver transplantation.
    • 98
    Tacrolimus‐Induced Diabetes in Rats Courses with Suppressed Insulin Gene Expression in Pancreatic Islets
    • 45
    • PDF
    Food-drug interaction of tacrolimus with pomelo, ginger, and turmeric juice in rats.
    • 37
    • PDF
    Tacrolimus (FK506) metabolite patterns in blood from liver and kidney transplant patients.
    • 70
    • PDF
    Nephrotoxicity following orthotopic liver transplantation. A comparison between cyclosporine and FK506.
    • 208